Exploring genetic loci of type 2 diabetes and cancer: a review

Diabetes and cancer are two heterogenous diseases which rapidly increasing in prevalence globally. A link between these non-communicable was first identified over 100 years ago however, recent epidemiological studies advances genomic research have provided greater insight into the association diabetes cancer. Epidemiological suggested that individuals with an increased risk of several types (including liver, pancreas, colorectal, breast endometrial) mortality. However, this is not observed all cancers, for example, there a reduced prostate diabetes. It has also been patients developing diabetes, highlighting relationship straightforward. Evidence shared genetic aetiology along numerous lifestyle clinical factors made it challenging to establish if causal or result confounding factors. This review takes pan-cancer approach highlight complexities interactions type 2 (T2D) development indicating where enabled diseases.